San Francisco, the iconic city by the bay, offers an unparalleled travel experience that draws visitors from all around the globe. Its historic charm, coupled with its diverse cultural fabric and breathtaking landscapes, makes it a must-visit destination. To truly immerse in the essence of this vibrant city, finding the perfect accommodation through Expedia hotels in San Francisco is key, offering travelers a wide array of options to fit every taste and budget.
The city boasts an impressive collection of hotels, from luxurious high-rises featuring panoramic views of the Golden Gate Bridge to cozy, boutique hotels nestled in the heart of its bustling neighborhoods. Expedia simplifies the process of finding these gems, providing comprehensive listings, customer reviews, and the best deals available. Whether you're in town for business, a romantic getaway, or a family vacation, Expedia's extensive selection ensures you'll find a hotel that not only meets but exceeds your expectations.
Moreover, utilizing Expedia to book your San Francisco hotel comes with its own set of advantages, such as exclusive discounts, reward points, and flexible cancellation policies. Recommendations and insights provided by Expedia enhance the decision-making process, allowing travelers to make informed choices based on their preferences and needs. This makes exploring San Francisco's iconic sights, from Alcatraz Island to the bustling streets of Chinatown, a seamless and enriching experience.
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Our Top 10
(Sorted by rating & number of reviews)
1. The St. Regis San Francisco Hotel
2. The Mosser Hotel
3. Argonaut Hotel, A Noble House Hotel
4. The Marker San Francisco Hotel
5. Hotel Whitcomb
6. Fairmont San Francisco Hotel
7. Four Seasons Hotel San Francisco
8. Hotel Garrett
9. Hotel Nikko San Francisco
10. Hotel Zetta San Francisco
Luxurious Expedia Hotels in San Francisco
Check Availability
San Francisco
Mar 23, 2026 - Mar 24, 2026
The St. Regis San Francisco Hotel
9.0
Good
(81 Reviews)
+ 79 photos
The St Regis San Francisco combines timeless elegance with modern innovation, standing as a beacon of luxury in the very heart of the city. Guests are greeted with a blend of high art and high tech, offering an ambiance that is both opulent and inviting. The hotel is renowned for its personalized butler service, ensuring every need is catered to with precision and grace. Each room is a masterpiece of design, featuring plush bedding, exquisite marble bathrooms, and breathtaking views of San Francisco. The on-site facilities include a spa, indoor infinity pool, and fine dining restaurant, all designed to pamper guests beyond their expectations. Located just steps from the Museum of Modern Art and Union Square, The St Regis provides an unmatched starting point for those eager to explore San Francisco in style.
Address:125 Third Street
Rating:
Good
9.0
(81 Reviews)
Rooms:260
Price: From 419$
The Mosser Hotel
7.3
Good
(1739 Reviews)
+ 136 photos
The Mosser Hotel is an excellent option for budget-conscious travelers, offering a unique blend of historical charm and modern efficiency. Located between Union Square and the Moscone Center, this hotel offers easy access to shopping, dining, and conference venues. An innovative feature of The Mosser is its shared-bathroom accommodations, which allow for even more savings without sacrificing cleanliness or convenience. The hotel also features rooms with private bathrooms, catering to guests who prefer more privacy. With its in-house recording studio, The Mosser especially appeals to music enthusiasts looking for an affordable stay in the city's vibrant downtown area.
Address:54 Fourth Street
Rating:
Good
7.3
(1739 Reviews)
Rooms:166
Price: From 64$
Boutique Expedia Hotels in San Francisco
For those looking to immerse themselves in San Francisco's unique charm, boutique hotels offer a more personalized, intimate experience. These establishments are distinguished by their originality, flair, and connection to the local culture, making them intriguing choices for travelers seeking something beyond the ordinary. The boutique Expedia hotels in San Francisco are carefully curated to blend distinctive design with exceptional service, creating memorable stays. Located in vibrant neighborhoods, these hotels provide easy access to local shops, cafes, and the essence of San Francisco's eclectic spirit. The following selections highlight the best of what boutique accommodations have to offer, as found on Expedia.
Argonaut Hotel, A Noble House Hotel
8.6
Good
(1859 Reviews)
+ 318 photos
The Argonaut Hotel embodies the adventurous spirit of San Francisco, situated in the historic Fisherman's Wharf district. This nautical-themed boutique hotel captures the essence of the city's maritime past, with decor and memorabilia that pay homage to its coastal heritage. The rooms are spacious and feature whimsical maritime design elements, offering views of the bay or the city. The on-site restaurant, The Blue Mermaid, serves fresh seafood and classic San Franciscan fare in a cozy, welcoming environment. Guests can also take advantage of the complimentary bike rentals to explore the scenic surroundings. The Argonaut Hotel's unique charm and prime location make it an ideal choice for travelers seeking a memorable stay in the lively heart of San Francisco's waterfront.
Address:495 Jefferson Street
Rating:
Good
8.6
(1859 Reviews)
Rooms:252
Price: From 179$
The Marker San Francisco Hotel
8.2
Good
(686 Reviews)
+ 274 photos
The Marker San Francisco brings a vibrant fusion of art deco elegance and modern luxury to the heart of the city's Theater District. This boutique hotel is celebrated for its distinctive architecture, colorful interiors, and commitment to sustainability. Each guest room is a work of art, featuring bold patterns, deep colors, and luxurious amenities that cater to both comfort and style. The hotel's lobby is a lively hub for guests to mingle, adorned with an eclectic mix of art and decor. The on-site restaurant offers a menu that highlights local, organic ingredients, perfectly complementing the creative ambiance. The Marker San Francisco stands as a testament to the city's inventive spirit, making it a top choice for those who appreciate the finer details and a flair for the dramatic.
Address:501 Geary Street
Rating:
Good
8.2
(686 Reviews)
Rooms:208
Price: From 149$
Family-Friendly Expedia Hotels in San Francisco
San Francisco is a wonderland for travelers of all ages, with its family-friendly attractions and activities that cater to the young and the young at heart. The family-friendly Expedia hotels in San Francisco go the extra mile to welcome children, offering amenities and accommodations designed to ensure a comfortable and enjoyable stay for guests of all ages. From rooms with bunk beds to hotels offering child-friendly menus and activities, these selections understand the importance of catering to family needs. Located near major attractions such as the Exploratorium, Golden Gate Park, and the San Francisco Zoo, these hotels serve as the perfect base for exploring the city's family attractions. Delve into our top picks for family-friendly accommodations to make your San Francisco trip a memorable one for the entire family.
Hotel Whitcomb
7.0
Good
(1578 Reviews)
+ 234 photos
Hotel Whitcomb is a historic hotel that offers an affordable stay in the very heart of San Francisco. While the hotel embraces its historic charm, it also provides guests with modern conveniences such as complimentary Wi-Fi and access to a fitness center. Its central location on Market Street makes it an excellent base for exploring the city, with easy access to public transportation and attractions like the Orpheum Theater. The Hotel Whitcomb's Victorian architecture and classic interiors offer a glimpse into San Francisco's past, all while providing the comforts expected by today's travelers on a budget.
Address:1231 Market Street
Rating:
Good
7.0
(1578 Reviews)
Rooms:445
Price: From 93$
Fairmont San Francisco Hotel
8.1
Good
(1123 Reviews)
+ 647 photos
Fairmont San Francisco is an institution, a grand dame that has stood atop Nob Hill since 1907, offering guests a taste of the city's storied past along with modern luxuries. This landmark hotel captures the essence of a bygone era through its magnificent architecture and historic decor, while providing contemporary comforts and amenities. The rooms and suites are elegantly appointed, many featuring stunning views of the city and the bay. The hotel's dining experiences are just as impressive, with several restaurants and bars that cater to discerning tastes. Guests can also enjoy the well-equipped fitness center and the famous Afternoon Tea served in the opulent lobby. The Fairmont is not just a hotel but a piece of San Francisco's history, making it a perfect pick for travelers seeking both luxury and legacy.
Address:950 Mason Street
Rating:
Good
8.1
(1123 Reviews)
Rooms:591
Price: From 241$
Budget-Friendly Expedia Hotels in San Francisco
San Francisco is known for its steep hills, iconic landmarks, and unfortunately, its high costs of living and visiting. However, that doesn't mean you have to break the bank to enjoy what the city has to offer. The budget-friendly Expedia hotels in San Francisco provide affordable options without compromising on quality or location. These hotels offer basic yet comfortable accommodations, with easy access to public transportation and popular attractions like the Golden Gate Bridge and Lombard Street. For travelers on a budget, these hotels are perfect for stretching your dollars further, ensuring you can enjoy more of what San Francisco has to offer. Explore our top selections for budget-friendly stays that promise value without sacrificing the San Francisco experience.
Four Seasons Hotel San Francisco
9.0
Good
(188 Reviews)
+ 177 photos
Four Seasons Hotel San Francisco offers a sanctuary of sophistication in the center of the city, marrying understated elegance with unmatched hospitality. Located within walking distance to Union Square and the Financial District, this hotel serves as a peaceful retreat amidst the urban hustle. The rooms are designed with luxury and comfort in mind, featuring spacious layouts, contemporary decor, and panoramic views of San Francisco. Guests have access to an exclusive fitness center and spa, along with dining options that highlight local and seasonal ingredients. The service at the Four Seasons is attentive yet unobtrusive, ensuring a stay that is both personalised and relaxing. This hotel is not just a place to stay; it's an experience, offering a glimpse into the luxurious side of San Francisco living.
Address:757 Market Street
Rating:
Good
9.0
(188 Reviews)
Rooms:277
Price: From 45$
Hotel Garrett
7.2
Good
(308 Reviews)
+ 138 photos
Good Hotel is branded as the first hotel with a conscience in San Francisco, boasting eco-friendly practices and a design that's both modern and minimalistic. This budget-friendly hotel is situated in the SoMa district, close to attractions like the San Francisco Museum of Modern Art and the Civic Center. The rooms are compact yet comfortable, focusing on essential amenities that cater to environmentally conscious travelers. This hotel proves that staying in San Francisco on a budget can also mean making environmentally responsible choices.
Address:112 7Th Street
Rating:
Good
7.2
(308 Reviews)
Rooms:117
Price: From 99$
Hotel Nikko San Francisco
8.7
Good
(3255 Reviews)
+ 238 photos
Hotel Nikko San Francisco offers a blend of high-end hospitality with family-friendly touches, making it a prime choice for those traveling with little ones. The hotel is known for its spacious rooms equipped with amenities suitable for families, such as mini-fridges and in-room entertainment. An indoor pool with a sky dome is one of the highlights for families, providing a safe and engaging environment for children to splash around. The hotel's central location means attractions like the Children's Creativity Museum are easily accessible. With its renowned Asian hospitality and attention to detail, Hotel Nikko ensures a comfortable stay for families looking to explore the heart of San Francisco.
Address:222 Mason Street
Rating:
Good
8.7
(3255 Reviews)
Rooms:532
Price: From 186$
Hotel Zetta San Francisco
7.8
Good
(841 Reviews)
+ 85 photos
Hotel Zetta San Francisco is a haven for creative souls and tech-savvy travelers, blending cutting-edge technology with innovative design. Situated in the vibrant SoMa district, this hotel is a stone's throw from the city's most dynamic tech companies and cultural attractions. The guest rooms are a testament to modern living, equipped with smart TVs, customizable lighting, and reclaimed wood furnishings, reflecting the hotel's commitment to sustainability. The lobby and common areas serve as creative spaces, featuring art installations and a giant Plinko game wall. The in-house restaurant and bar offer contemporary Californian cuisine and inventive cocktails, catering to the discerning tastes of its guests. Hotel Zetta provides a unique blend of luxury and creativity, making it a standout choice for those wishing to experience the modern pulse of San Francisco.
Address:55 5Th Street
Rating:
Good
7.8
(841 Reviews)
Rooms:116
Price: From 114$
Hyatt Regency San Francisco Hotel
8.7
Good
(1790 Reviews)
+ 213 photos
Hyatt Regency San Francisco stands out for its scenic location on the Embarcadero waterfront and its proximity to family favorites like Pier 39 and the Ferry Building Marketplace. This hotel caters to families with spacious accommodations, including rooms with stunning bay views that can captivate children and adults alike. The hotel's on-site restaurant offers diverse menu options with kid-friendly meals to satisfy little diners. Furthermore, the Hyatt Regency's staff are known for their welcoming attitude towards families, providing recommendations and assistance to ensure a joyful San Francisco experience. With easy access to nearby attractions and comfortable lodging, it's an ideal pick for families.